Re-entering US using H1B after 6 months of vacation outside the country

[laddu0]

Hi Guys:

My wife is out of country from October 2010. She was working on H1B. After birth of our son, she went to India for 6 month vacation. Will there be any issues if she re-enters US using H1B as she is having a job to continue with her employer.

What are all the documents I need to take.

Please advice.

Thanks
LADDU